mRNA malaria vaccine
The problem
Despite decades of research, traditional malaria vaccines have limitations, including poor efficacy and interference from previous infection.
The solution
We developed an mRNA vaccine incorporating a potent vaccine adjuvant which enables the generation of liver-resident memory T cells to prevent malaria.
The impact
Our mRNA vaccine shows promise for effective protection against malaria, particularly in malaria-endemic regions, as it is not impaired by previous exposure to blood-stage infection, unlike traditional vaccines.
Research team
mRNA and lipid nanoparticles team
Related story
Scientific breakthrough harnesses mRNA technology to develop powerful malaria vaccine
A new mRNA vaccine targeting immune cells in the liver could be the key to tackling malaria, a disease that causes over half a million deaths each year according to the World Health Organization, yet has no effective long-lasting vaccine.