Refining mRNA production to generate liver immunity

Learn more about how the mRNA and lipid nanoparticles team is developing scalable mRNA purification methods to improve vaccine effectiveness.

The problem

The manufacturing and purification methods used to produce mRNA can significantly impact their ability to induce liver-resident memory T cells (Trm), which are crucial for effective immune responses.

Our goals

We are developing scalable methods to purify mRNA and are working to identify the factors that induce Trm cells, with the goal of creating highly pure mRNA products.

The impact

Our project aims to establish best practices for mRNA purification and analytical protocols, which could lead to more effective and targeted immune responses, advancing vaccine technology and manufacturing methodologies for liver diseases like malaria, hepatitis, and liver cancer.

This project is funded by RNA Platform Fast Start.

Research team

A group of nine people sitting and standing around a table.

mRNA and lipid nanoparticles team

Design and synthesis of vaccine adjuvants and ionisable lipids and subsequent use in vaccines.
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Fast Start projects

A set of highly collaborative research projects that can immediately build capability for the platform.